Stepping back a bit, studies have shown repeatedly that certain regions of the cerebral cortex (the outermost layer of the brain) get thinner as children develop. And at a mere 3mm thick, on average, studies have reported that kids can apparently lose close to 1mm of gray matter by adulthood. Various hypotheses have been put forth to explain these huge losses. For example, it is established that gray matter cells and their connections can be naturally ‘pruned’, presumably to promote a more efficient brain. So perhaps extensive pruning in young brains could explain the thinning. Alternatively, we know that our brains expand during development. Perhaps the cortex gets stretched in the process? The new research certainly does not rule out these processes, and in fact finds evidence for the latter. However, the new work does suggest that a prominent change has gone undetected, due to the limitations of prior measurements. More specifically, the present study shows that when measured with quantitative MRI (or qMRI), it appears that young brains are actually becoming more myelinated. That’s a good thing, but it may be messing up estimates of cortical thickness (the gray matter). Myelin is the ‘white’ in white matter. It’s a fatty sheath that insulates many nerve fibers and allows faster neurotransmission. The problem is, measurements of gray matter thickness critically depend on detecting the border between white and gray matter. As Natu and Kirilina have found out, this limit can be obscured and cortical thickness underestimated if myelination increases during development. The researchers obtained these results by examining adults and children using state-of-the-art quantitative MRI techniques. Evgeniya Kirilina, who is working in the department of Neurophysics at MPI CBS, offers a word of caution. ‘The fact that the cortex thins during development is well established, even with histological methods. We are not claiming that thinning does not occur. But estimates may be off in some cases due to concurrent myelination.’ The team was actually looking at three specialized patches of the brain in the higher visual cortex. Despite their close proximity, each showed a unique developmental pattern, underlining the need for cautious interpretation. The face and word recognition areas showed the myelination effect described above, whereas the place recognition area showed apparent thinning but no indication of myelination. Instead, it seemed to structurally change, stretching over time. Highlighting the important link between structure and function, the differences in myelination of these functionally specialized regions were confirmed in post-mortem brains of adults, using both ultra-high field MRI and histology. The implications of these new findings are quite broad. Decades of work will need to be revisited and assessed for accuracy. For example, there is rich literature suggesting that the thickness of the cortex changes when learning new skills. It will now need to be determined whether myelination also plays a role. Further, the degradation of myelin can lead to debilitating diseases. This is exactly what occurs in Multiple Sclerosis. More accurate measurement techniques like qMRI promise to improve our detection, monitoring, and treatment of such conditions. Reference: “Apparent thinning of human visual cortex during childhood is associated with myelination” by Vaidehi S. Natu, Jesse Gomez, Michael Barnett, Brianna Jeska, Evgeniya Kirilina, Carsten Jaeger, Zonglei Zhen, Siobhan Cox, Kevin S. Weiner, Nikolaus Weiskopf and Kalanit Grill-Spector, 23 September 2019, Proceedings of the National Academy of Sciences.DOI: 10.1073/pnas.1904931116
