444 women who were trying to become pregnant took part in the study, which assessed the allostatic load of the participants. Allostatic load refers to the cumulative “wear and tear” of chronic stress and life events. Women with higher allostatic load scores—based on nine indicators such as blood pressure, cortisol, blood sugar, noradrenaline, and cholesterol—were less likely to become pregnant within a year. For example, the women with an allostatic load score of 5-6 would have a 59% reduction of fecundability compared with those with scores of 0. “What we found provides a new idea for preconception counseling. But obviously, how to objectively assess the stress is a complex scientific question, and how to intervene and reduce the impact of chronic stress is a burning problem, which are all things we need to study further,” said senior author Bei Wang, PhD, of Southeast University in Jiangsu, China. Reference: “Female fecundability is associated with pre-pregnancy allostatic load: Analysis of a Chinese cohort” by Xiang Hong, Jiechen Yin, Fanqi Zhao, Wei Wang, Xiaoling Ding, Hong Yu and Bei Wang, 21 September 2022, Acta Obstetricia et Gynecologica Scandinavica.DOI: 10.1111/aogs.14443
